Study on tunable crosslinking anion exchange membranes fabrication and degradation mechanism. On examination of the pharmacokinetic data, Clp(9.9 ml *symbol* kg sup -1 *symbol* min sup -1) and Vss‘(257 ml/kg) from one of the younger control patients were determined to be outliers based on Dixon's criterion, or r-ratio test, comparing the distance of one end observation from its nearest neighbor with the range of all observations. Parker CJR, Hunter JM, Snowdon SL: Effect of age, sex and anaesthetic technique on the pharmacokinetics of atracurium. This site needs JavaScript to work properly. Figure 1. Pharmacokinetic data was described by a biexponential function. Nucleophilic ?-(Secondary Amino)-alkylationvia Metalated Nitrosamines. Novel cross-linked anion exchange membrane based on hexaminium functionalized poly(vinylbenzyl chloride). Rational molecular design of anion exchange membranes functionalized with alicyclic quaternary ammonium cations. -, Br J Anaesth. [30]. Nigrovic V, Banoub M: Pharmacokinetic modelling of a parent drug and its metabolite: Atracurium and laudanosine. Anaesthesia 1986; 41:375-81. The pharmacodynamic response was described by the neuromuscular blocking profile. Abnormal cisatracurium pharmacodynamics and pharmacokinetics among patients with severe aortic regurgitation during anesthetic induction. The Vss was larger in the elderly (126 +/- 16 vs. 108 +/- 13 ml/kg), although the clearances were the same for the two groups (5.0 +/- 0.9 vs. 4.6 +/- 0.8 ml.kg(-1).min(-1). Kitts JB, Fisher DM, Canfell PC, Spellman MJ, Caldwell JE, Heier T, Fahey MR, Miller RD: Pharmacokinetics and pharmacodynamics of atracurium in the elderly. J Pharmacokinet Biopharm 1976; 4:443-67. Aromatic Polymer Electrolyte Membranes as Hydroxide Conductors. 1989 Nov;63(5):598-600 Thesyn andanti Steric Course in Bimolecular Olefin-Forming Eliminations. All processed samples were placed in ice within 2 min, 10 s of collection and frozen within 30 min of collection to prevent degradation. Onset of paralysis to 90% twitch depression was delayed by approximately 1 min in the elderly group. Renal excretion of unchanged cisatracurium accounted for 9–15% of the injected dose in the elderly patients and 11–24% of the dose in the young patients. Stability of ionic liquids in Brønsted-basic media. Atracurium, a nondepolarizing muscle relaxant, is eliminated through several pathways, including Hofmann elimination (spontaneous degradation in plasma and tissue at normal body pH and temperature) and ester hydrolysis (catalysis by nonspecific esterases). Plasma concentration of cisatracurium and laudanosine were determined using a validated high performance liquid chromatographic method with fluorescence detection. Get article recommendations from ACS based on references in your Mendeley library. W.H. Angewandte Chemie International Edition in English. -, Anesthesiology. Wagner J: Linear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of polyexponential equations which have been fitted to the data. When we participate in the growth of children, a sense of wonder must take hold of us, providing for us a sense of future. One or More CC Bond(s) by Elimination of S, Se, Te, N, P, As, Sb, Bi, Si, Ge, B or Metal Functions. Demographic, pharmacokinetic, and pharmacodynamic data appear in Table 1. Cisatracurium could be detected in plasma up to 120 min in 18 patients (10 elderly and 8 young), and in the remaining 6 patients (2 elderly and 4 young), up to 90 min. In most patients, laudanosine concentrations were quantifiable until up to 4 h (one predicted elimination half-life for laudanosine following atracurium administration [4]). This tendency, known as the Hofmann alkene synthesis rule, is in contrast to usual elimination reactions, where Zaitsev's rule … NLM Neue Reaktionen von Phosphinalkylenen und ihre präparativen Möglichkeiten II. Br J Anaesth 1987; 59:211-7. Br J Anaesth 1989; 63:661-6. Because elimination of atracurium occurs in …