Bull. In addition, kaempferol is a key component in Punica granatum, which has been found to act as an effective protector against UVB-induced photodamage and aging in cultured skin fibroblasts (Int. Your use of this website indicates your agreement to these terms and those published here. Another study found that kaempferol, together with other flavonoids such as apigenin and luteolin, has analgesic and anti-inflammatory effects contained in the Cassia siamea Lam. Pharmacol. The investigators concluded that kaempferol is among the flavonoids or plant extracts containing them that may be useful as an agent to protect against photoaging and to treat some cutaneous inflammatory conditions (Planta Med. 2013 June 27 [doi:10.1111/jdv.12204, Manage Your Dermatology Practice: Managing Difficult Patient Encounters, Expert Insights in Hidradenitis Suppurativa, Treating Patients with Acne by Telemedicine in the Era of COVID-19, Nurse Practitioners / Physician Assistants. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners. Benefits to the skin include: Anti-inflammatory and anti-aging effects. demonstrated that kaempferol alleviated burn injuries in mice and that expression of tumor necrosis factor–alpha (TNF-alpha) induced by burn injuries was reduced by kaempferol. Significantly, kaempferol is known to exhibit anticancer, anti-inflammatory, antioxidant, cytoprotective, and antiapoptotic activity (Cancer Prev. 2010;80:2042-9; Exp. Another study found that Kaempferol-3-O-sophoroside (KPOS) possessed barrier integrity activity, inhibitory activity on cell adhesion, and migration to endothelial cells by blocking the activation of NF-κB expression and production of TNF-α which then endorsed its usefulness as therapy for vascular inflammatory diseases. 2014;62:3750-8). In a study, it was found out that flavonols quercetin and kaempferol significantly increased alkaline phosphate (ALP) activity which then can stimulate osteoblastic activity. (Tokyo) 2012;60:1171-5). The information on this site is provided for educational and entertainment purposes only. Truth Publishing International, LTD. is not responsible for content written by contributing authors. It helps to prevent arteriosclerosis hindering oxidation of low density lipoprotein and platelet formation in blood. Evidence suggests reasons for confidence that kaempferol can play a role in skin health. 2006;54:2951-6; Cancer Prev. Kaempferol, a yellow-colored powder, is a flavonoid that can be found in various natural resources such as apples, onions, leeks, citrus fruits, grapes, red wines, and ginkgo biloba. Health Benefits. http://www.phytochemicals.info/phytochemicals/kaempferol.php, Linolelaidic acid is an omega-6 trans fatty acid and a geometric isomer of linoleic acid.…, Fiber isn’t a single nutrient but a family of plant-based nutrients that are generally resistant…, Niacin is more commonly recognized as vitamin B3 and is part of the B-complex vitamins.…, Flavonoids constitute a large class of phytochemicals that are widely distributed in the plant kingdom,…, Lutein and Zeaxanthin facts and food sources, Vitamin K2 food sources and health benefits, Facts and Food Sources of Linolelaidic acid. (Phila) 2014;7:958-67; Biochem. In a study, it was found out that flavonols quercetin and kaempferol significantly increased alkaline phosphate (ALP) activity which then can stimulate osteoblastic activity. Anti-inflammatory as well as depigmenting activity was found by Rho et al. Aside from its cancer-fighting properties, kaempferol acts as an antioxidant and protects the body from damaging free radicals, which are harmful by-products of oxygen-based reactions. Kaempferol is a strong antioxidant which helps to prevent oxidative damage of cells, DNA and lipids. Do you have information you’d like to share on kaempferol? Res. Study shows that kaempferol acts as chemopreventive agent that inhibits cancer cells formation. Health Benefits of Kaempferol Kaempferol is a strong antioxidant which helps to prevent oxidative damage of cells, DNA and lipids. in 2002 revealed that four kaempferol glycosides are key active ingredients in the flowers of Prunus persica, which has long been used in traditional Chinese medicine to treat skin disorders (J. Cosmet. Furthermore, it acts as a phytoestrogen, which regulates estrogen levels in the body. In the investigation of the effects of kaempferol -3,7-O- (alpha)-dirhamnoside (kaempferitrin) on serum glucose levels for its antioxidant potential and hypoglycemic effect found that the hypoglycemic effect of kaempferitrin in diabetic rats was evident at all doses tested (50, 100, and 200 mg/kg), and this profile was maintained throughout … 2002;53:27-34). Kaempferol is one of the many flavonoids found in foods alongside others like luteolin and quercetin. Unauthorized use prohibited. Pharmacol. They concluded that their findings suggest the possible application of kaempferol to treat thermal burn–induced skin injuries (BMB Rep. 2010;43:46-51). Skin protection: antioxidant and anti-inflammatory activity. Venereol. Dermatol. Significantly, in terms of topical delivery, Chao et al. Another study also revealed that kaempferol has a potential clinical use for the treatment of allergic asthma. MDedge: Keeping You Informed. These and other findings led the investigators to conclude that A. rossii and its active ingredients kaempferol and quercetin may be effective agents for the treatment of immediate-type hypersensitivity (J. Agric. Kaempferol has been found to have hypoglycemic and antioxidant effects. The phytonutrient was also found to have antimicrobial effects. It is a yellow crystalline solid having melting point of 276–278 °C (529–532 °F). It is not intended as a substitute for professional advice of any kind. 1. Kaempferol is becoming an exciting nutritional compound with promise for reducing the risks of developing certain types of cancer and inflammatory-based diseases. See more with MDedge! 2010;80:2042-9). reported in 2007 that kaempferol and quercetin potently inhibited recombinant human MMP-1, and both flavonols along with apigenin and wogonin were found to be strong inhibitors of MMP-1 induction in 12-O-tetradecanoylphorbol-13-acetate–treated human dermal fibroblasts. Research on kaempferol is scarce in humans in supplemental form, but in vitro research seems promising. Work by Kim et al. Acad. Kaempferol also hindered p38 mitogen-activated protein kinase c-Jun N-terminal kinase (JNK) activation. Dermatol. Dermatol. found that kaempferol acted as a safe and potent inhibitor of solar ultraviolet-induced mouse skin carcinogenesis that acted by targeting RSK2 and MSK1 (Cancer Prev. Copyright © 2020 Frontline Medical Communications Inc., Parsippany, NJ, USA. found that extracts of Aceriphyllum rossii (native to Korea and China) and its active constituents, quercetin and kaempferol, blocked secretion of beta-hexosaminidase and histamine; lowered the production and mRNA expression of interleukin-4 and TNF-alpha; and reduced prostaglandin E2 and leukotriene B4 synthesis as well as the expression of cyclooxygenase-2 (COX-2) and 5-lipoxygenase.